Traditional Chinese Medicine Healing Herbs(TCMHH)

Prescriptions for Tranquilizing the Mind with Weighty Sedatives

Zhu Sha An Shen Wan (朱砂安神丸)

朱砂安神丸 Zhusha Anshen Wan
By the TCMHH editorial team Not medically reviewed How we work Updated 6 Oct 2026
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Name

Cinnabaris Sedative Bolus

The Prescription of 朱砂安神丸

Source

The book Yi Xue Fa Ming

Ingredients

Zhu Sha (Cinnabaris) 15 g,Huang Lian (Rhizoma Coptidis) 18 g,Zhi Gan Cao (Radix Glycyrrhizae Preparata) 16 g,Sheng Di Huang (Radix Rehmanniae) 8 g,Dang Gui (Radix Angelicae Sinensis) 8 g.

Explanation

Zhu Sha: One of the principal drugs, being sweet in taste and cold and heavy in nature, tranquilizing the mind.

Huang Lian: The other principal drug, being bitter in taste and cold in nature, clearing away heat to relieve vexation.

Dang Gui: Nourishing blood.

Sheng Di: Replenishing Yin.

Gan Cao: Tempering the actions of all the ingredients.

The Effect of 朱砂安神丸

Effect

Purging pathogenic heat and nourishing Yin to tranquilize the mind.

Indications

Syndrome due to exuberance of the heart-fire and insufficiency of Yin-blood, marked by vexation, insomnia, dreaminess, palpitation or even severe palpitation, burning sensation in the chest, reddened tongue, and thready rapid pulse; including such diseases with the above symptoms as neurosism, myocarditis and mental depression.

Administrations

The ingredients are ground into fine powder and made into pills. 6-9 g of the pills is taken with boiled water before sleep in the night. This prescription may also be used in the form of decoction. In so doing, the doses of the drugs should be re-adjusted according to the proportions of the drugs in the original prescription. Zhu Sha is refined with water and taken with the decoction. Since Zhu Sha has toxicity, this prescription should not be used regularly, and Zhu Sha should be used in smaller dose.

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Sources and further reading

We cite classical materia medica and modern reference works. This article is health education, not medical advice.

  • Shennong Bencao Jing (The Divine Farmer's Materia Medica), Han dynasty.
  • Bencao Gangmu (Compendium of Materia Medica), Li Shizhen, 1578.
  • Chinese Pharmacopoeia, current edition — identity, quality and safety monographs.
  • NCCIH and WHO reference material on traditional medicine safety.

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